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How binge drinking affects male, female brains?

IANS  |  New York 

While affects of both males and females, the effect of in an area of the brain linked to was found to be different, finds a new study.

Repeated was found to significantly alter molecular pathways in the nucleus accumbens -- a region of the brain linked to

But, in females the genes linked to hormone signalling and immune function are altered, whereas in males genes related to nerve signalling are affected.

The study has significant implications for the as they emphasise the importance of tailoring effective therapies towards male and female patients, said researchers led by Deborah Finn, at Oregon and

Repeated can be a risk factor for the development of alcohol dependence.

For the study, published in the journal Frontiers in Genetics, the team analysed in nucleus accumbens.

"We examined the effect of repeated binge drinking on the expression of 384 genes previously identified as important in and mood disorders," Finn said.

Of a total of 106 genes regulated by binge drinking, only 14 were regulated in both males and females, representing common targets to binge drinking. Interestingly, only 4 of these 14 genes were regulated in the same direction and the top 30 genes regulated by binge drinking in each sex differed markedly.

"We have shown that pharmacologically manipulating a pathway in both sexes that only was affected by binge drinking in males did not decrease binge drinking in females; binge drinking was only decreased in males," Finn explained.

She noted that a consideration of sex is critical in the development of potential pharmacological

--IANS

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(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Tue, September 11 2018. 17:24 IST
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