You are here: Home » PTI Stories » National » News
Business Standard

Alcohol use may increase Alzheimer's risk: Study

Press Trust of India  |  Washington 

Alcohol consumption impedes the ability of brain cells to keep clear of plaques, and may contribute to the development of disease, according to a study.

Researchers from the at Chicago in the US found that some of the genes affected by alcohol and are also implicated in processes that clear beta - the protein that forms globs of plaques in the brain and which contributes to neuronal damage and the associated with

Previous studies investigating the effects of alcohol consumption on disease have been controversial - some have indicated that alcohol has a protective effect, while others have pointed to a deleterious role for alcohol in the development of the

Recent research has suggested that alcohol consumption, and its impact on the immune system and in the brain, may be the vehicle through which alcohol might exert its influence on the development of

However, no previous studies have directly evaluated which genes are affected by alcohol in cells in the brain involved in protecting against

The cell-based study, published in the Journal of Neuroinflammation, suggests that alcohol may impede the clearance of beta in the brain.

Douglas Feinstein, a at the University of Illinois, and colleagues wanted to determine which genes were affected by both alcohol and high levels of in microglial cells.

These are cells that support neural cells in the brain and elsewhere in the body.

One of their functions is to engulf and digest the amyloid beta protein plaques characteristic of Alzheimer's disease in a process known as phagocytosis.

Microglial cells are also known to express high levels of due to

The researchers exposed rat microglial cells to alcohol, called cytokines, or alcohol and cytokines in the lab for 24 hours, and then looked at changes in under each condition.

They also looked at the impact of alcohol exposure on the cells' ability to engulf amyloid beta.

The team found that was altered for 312 genes under the alcohol condition; for 3,082 for the pro-inflammatory condition, and 3,552 for the alcohol and pro-inflammatory condition.

Changes in - either an increase or decrease in expression compared to normal levels - averaged about 16 per cent and ranged from a 50 per cent decrease to a 72 per cent increase.

Just a handful of genes were involved in both phagocytosis and inflammation.

"Among the genes we saw altered were many involved in phagocytosis, which is the first time this has been shown, Feinstein said.

"While these studies were performed in isolated cells, our results suggest that alcohol impedes the ability of mircroglia to keep the brain clear of amyloid beta and may contribute to the development of Alzheimer's disease," he said.

After the researchers exposed the cells to alcohol levels at doses that are comparable to those found in humans after binge drinking or in heavy drinkers, they found that microglial phagocytosis was significantly suppressed by about 15 per cent after one hour.

"We didn't continue the study to see whether phagocytosis was further impaired after longer exposures to alcohol but it appears that these changes in microglial cells could be a contributing factor to the development of Alzheimer's disease," Feinstein said.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Tue, June 05 2018. 16:00 IST
RECOMMENDED FOR YOU