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New drug delivery system may help prevent infections

Press Trust of India  |  Washington 

Scientists have discovered a new system that could help prevent

The researchers at in the US synthesised nanostructured silica particles, considered to be promising drug carriers, that contained payloads of an antimicrobial agent.

They found that the particles were effective at killing two human bacterial pathogens, according to the study published in the Journal of The

The new mechanism allows compounds to slowly release antimicrobials into local environments, resulting in high amounts of the molecule in a specific location.

This is a different scenario than when are taken orally and they become widely distributed throughout the body.

"Interestingly, the particles were more effective at killing the than the antimicrobial was, which may highlight a more efficient mechanism for drug delivery," said Jeffrey Boyd, an associate at

are rapidly evolving and becoming resistant to antimicrobials -- agents that kill or prevent the growth of microorganisms such as bacteria, viruses or fungi.

The findings could help develop an antimicrobial therapy that would prevent or the growth of in unwanted locations, researchers said.

"The new materials we have designed and built allow antibacterials to be more potent and have the ability to wipe out bacteria at smaller concentrations than the antibacterials can do on their own," said Tewodros Asefa, a at

"This is because the newly designed nanomaterials allow the antibacterials to be localised, released slowly and attack the microorganism more effectively," Asefa said.

Researchers said the study could lead to the development of new microscopic particles containing drugs, antiseptics or pesticides that may increase the effectiveness of the therapy and aid in preventing antibacterial resistance.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Wed, October 10 2018. 15:10 IST
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