You are here: Home » PTI Stories » National » News
Business Standard

New vaccine for breast cancer shows promise

Press Trust of India  |  Washington 

Early clinical trial of a new breast cancer vaccine has shown it is safe for use in patients with advanced form of the disease, scientists say.

Preliminary evidence also suggests that the vaccine primed the patients' immune systems to attack tumour cells and helped slow the cancer's progression.

The new vaccine causes the body's immune system to home in on a protein called mammaglobin-A, found almost exclusively in breast tissue.

The protein's role in healthy tissue is unclear, but breast tumours express it at abnormally high levels, past research has shown.

"Being able to target mammaglobin is exciting because it is expressed broadly in up to 80 per cent of breast cancers, but not at meaningful levels in other tissues," said senior author William E Gillanders, professor of surgery at Washington University School of Medicine in St Louis.

"In theory, this means we could treat a large number of breast cancer patients with potentially fewer side effects," Gillanders said.

The vaccine primes a type of white blood cell, part of the body's adaptive immune system, to seek out and destroy cells with the mammaglobin-A protein.

In the smaller proportion of breast cancer patients whose tumours do not produce mammaglobin-A, this vaccine would not be effective, researchers said.

In the new study, 14 patients with metastatic breast cancer that expressed mammaglobin-A were vaccinated.

According to the authors, patients experienced few side effects, reporting eight events classified as mild or moderate, including rash, tenderness at the vaccination site and mild flu-like symptoms.

Although the trial was designed to test vaccine safety, preliminary evidence indicated the vaccine slowed the cancer's progression, even in patients who tend to have less potent immune systems because of their advanced disease and exposure to chemotherapy.

"Despite the weakened immune systems in these patients, we did observe a biologic response to the vaccine while analysing immune cells in their blood samples," said Gillanders.

"That's very encouraging. We also saw preliminary evidence of improved outcome, with modestly longer progression-free survival," Gillanders added.

The study appears in the journal Clinical Cancer Research.

Dear Reader,

Business Standard has always strived hard to provide up-to-date information and commentary on developments that are of interest to you and have wider political and economic implications for the country and the world. Your encouragement and constant feedback on how to improve our offering have only made our resolve and commitment to these ideals stronger. Even during these difficult times arising out of Covid-19, we continue to remain committed to keeping you informed and updated with credible news, authoritative views and incisive commentary on topical issues of relevance.
We, however, have a request.

As we battle the economic impact of the pandemic, we need your support even more, so that we can continue to offer you more quality content. Our subscription model has seen an encouraging response from many of you, who have subscribed to our online content. More subscription to our online content can only help us achieve the goals of offering you even better and more relevant content. We believe in free, fair and credible journalism. Your support through more subscriptions can help us practise the journalism to which we are committed.

Support quality journalism and subscribe to Business Standard.

Digital Editor

First Published: Mon, December 01 2014. 15:30 IST