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Drug prescribed to BP patients can increase risk of sudden cardiac arrest, claims study


A study conducted recently has observed that the common drug used for treating and (chest pain) is associated with an increased risk of out-of-hospital sudden

Sudden causes around half of the cardiac deaths in and one in five natural deaths. The stops pumping after a (ventricular fibrillation/ ); this can prove to be lethal in minutes if untreated. The results from the European Sudden network (ESCAPE-NET) were presented today at EHRA 2019. It was set up to find the causes of arrhythmias so that it can be prevented. ESCAPE-NET is backed by the European Rhythm Association (EHRA) of the (ESC) and the (ERC).

Dr Hanno Tan, ESCAPE-NET project leader and cardiologist, Academic Medical Centre, Amsterdam, Netherlands, urged caution when interpreting these results. He said, "The findings need to be replicated in other studies before action could be taken by doctors or patients."

The study examined if nifedipine and amlodipine, dihydropyridines widely used for and angina, are linked with out-of-hospital cardiac arrest. The nifedipine doses most often used and studied in this investigation are 30 mg and 60 mg (90 mg is available but infrequently used) and the amlodipine doses are 5 mg and 10 mg. Standard practice is to start with a lower dose, then give a higher dose if blood pressure or are not sufficiently reduced.

The analysis was done using data from the Dutch Resuscitation Studies registry (ARREST, 2005-2011) and confirmed in the Danish Cardiac Arrest Registry (DANCAR , 2001-2014), both part of ESCAPE-NET. Patients with out-of-hospital cardiac arrest due to were enrolled, plus up to five controls per patient matched for age and sex. Controls were from the Dutch PHARMO Database Network and the general population in In total, the study included 2,503 patients and 10,543 controls in the ARREST analysis and 8,101 patients and 40,505 controls in the DANCAR analysis.


(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Sun, March 17 2019. 17:52 IST