The group, called the COVID-19 Research Outcomes Worldwide Network (CROWN) Collaborative, is testing whether the antimalaria drug Chloroquine can prevent COVID-19 infection or decrease its severity in front-line health-care workers. For this study, Chloroquine will be donated to the U.S. arm of the Chloroquine RepurpOsing to healthWorkers for Novel CORONAvirus mitigaTION (CROWN CORONATION) clinical trial.
The Collaborative and the trial are funded by the COV/0-19 Therapeutics Accelerator, an initiative with contributions from an array of public and philanthropic donors, including Bill & Melinda Gates Foundation. Conducted at multiple sites in North America, Europe, the UK and Africa, CROWN CORON ATION will evaluate the protective potential of weekly, twice weekly or daily doses of Chloroquine, when compared with placebo, in frontline healthcare workers at high risk of exposure to SARS-CoV-2. The trial aims to include at least 30,000 subjects across the frontline healthcare workers.
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NATCO has been supplying Chloroquine Phosphate Tablets, a USFDA approved drug, through its marketing partner to the United States since 2011. More recently NATCO's alternate facility in Vizag has also been approved to supply the same drug. Chloroquine Phosphate Tablets are indicated predominantly for the treatment of malaria.
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