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Avocado seed extract shows anti-inflammatory activity

IANS  |  New York 

Researchers have identified that an extract from seeds exhibited properties in a laboratory study.

The team, including from Penn State, said that it represents a potential source for novel compounds that could be developed as a or

The researchers developed the extract over the last decade as a and it is not known whether the compounds responsible for the extract's vibrant orange colour play any role in its ability to inhibit the production of pro-inflammatory mediators, said Lambert.

To determine the properties of the seed extract, the researchers used cell culture models and enzymes that are important in immune response and

A class of immune cells called macrophages were grown in petri dishes and activated with a pro-inflammatory stimuli in the presence or absence of the seed extract.

The researchers measured the production of important pro-inflammatory mediators and signalling pathways in the cells after treatment with the extract.

"The next step, before we can draw further conclusions about the anti-inflammatory activity of this avocado seed extract, will be to design animal model studies," Lambert explained.

"The level of activity that we see from the extract is very good. We saw inhibitory activity at concentrations in the low microgram-per-millilitre range, which is an acceptable amount of activity to justify further studies," Lambert added.

The discovery could be important because cancer, cardiovascular diseases, arthritis, and many more serious conditions are associated with chronic inflammation, suggests the study published in the journal Advances in and Nutritional Sciences.



(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Fri, March 15 2019. 18:44 IST