You are here: Home » News-IANS » Health-Medicine
Business Standard

Researchers identify gene to treat alcoholism

Topics
Health Medical Pharma

IANS  |  New York 

Researchers have identified a gene that could provide a new target for developing medication to prevent and treat alcoholism, according to a new study on mice.

Researchers at Oregon National Primate Research Center (ONPRC) in the US discovered a gene that had lower expression in the brains of non-human primates which voluntarily consumed heavy amounts of alcohol compared to those that drank less.

Furthermore, the team unraveled a link between alcohol and how it modulates the levels of activity of this particular gene.

Researchers discovered that when they increased the levels of the gene encoded protein in mice, they reduced alcohol consumption by almost 50 per cent without affecting the total amount of fluid consumed or their overall well-being.

The study modified the levels of the protein encoded by a single gene known as GPR39.

The prevalence rates of co-occurring mood and alcohol use disorders are high, with individuals with alcohol use disorder being 3.7 times more likely to have major depression than those who do not abuse alcohol.

Using a commercially available substance that mimics the activity of the GPR39 protein, the researchers found that targeting this gene dramatically reduced alcohol consumption in mice, showed the findings of the study published in the journal, Neuropsychopharmacology.

"The study highlights the importance of using cross-species approaches to identify and test relevant drugs for the treatment of alcohol use disorder," noted senior author Rita Cervera-Juanes, Research Assistant Professor at ONPRC.--IANS

pb/arm/ab

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

Dear Reader,


Business Standard has always strived hard to provide up-to-date information and commentary on developments that are of interest to you and have wider political and economic implications for the country and the world. Your encouragement and constant feedback on how to improve our offering have only made our resolve and commitment to these ideals stronger. Even during these difficult times arising out of Covid-19, we continue to remain committed to keeping you informed and updated with credible news, authoritative views and incisive commentary on topical issues of relevance.
We, however, have a request.

As we battle the economic impact of the pandemic, we need your support even more, so that we can continue to offer you more quality content. Our subscription model has seen an encouraging response from many of you, who have subscribed to our online content. More subscription to our online content can only help us achieve the goals of offering you even better and more relevant content. We believe in free, fair and credible journalism. Your support through more subscriptions can help us practise the journalism to which we are committed.

Support quality journalism and subscribe to Business Standard.

Digital Editor

First Published: Sat, February 09 2019. 15:50 IST
RECOMMENDED FOR YOU
RECOMMENDED FOR YOU