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Climate change may weaken human immunity: Study

Press Trust of India  |  Tokyo 

Heat waves may reduce the body's immune response to influenza, according to a study in mice which may have implications for how climate change may affect the future of and nutrition.

Climate change is predicted to reduce crop yields and nutritional value, as well as widen the ranges of disease-spreading insects, said researchers from the in Japan.

However, the effects of heat waves on immunity to had not been studied before.

The study, published in the journal PNAS, investigated how high temperatures affect mice infected with virus.

"is a I think this is why no one else has studied how high temperatures affect flu," said Takeshi Ichinohe, an at the

The virus survives better in dry, cold air, so it usually infects more people in winter.

However, Ichinohe is interested in how the body responds after

The researchers housed healthy, young adult female mice at either refrigerator-cold temperature (4 degrees Celsius), room temperature (22 C), or heat wave temperature (36 C).

When infected with flu, the of mice in hot rooms did not respond effectively.

Most affected by the high heat condition was a critical step between the immune system recognising and mounting a specific, adaptive response.

Otherwise, heat-exposed mice had no other significant changes to their immune system: They had normal reactions to vaccines injected under the skin.

Moreover, bacteria living in the gut, which are increasingly becoming regarded as important for health, remained normal in the mice living in hot rooms, researchers said.

Notably, mice exposed to high temperature ate less and lost 10 per cent of their body weight within 24 hours of moving to the hot rooms, they said.

Their weight stabilised by day two and then mice were infected by breathing in live virus on their eighth day of exposure to heat.

Mice living in heat wave temperatures could mount a normal immune response if researchers provided supplemental nutrition before and after

Researchers gave mice either glucose (sugar) or short-chain fatty acids, naturally produced by intestinal bacteria.

In experiments at room temperature, researchers surgically connected mice so that body fluids moved freely between underfed and normally fed mice, both infected with influenza.

The fluids from normally fed mice prompted the of underfed mice to respond normally to the

The results may shed light on the unfortunate experience of getting sick again while recovering from

"People often lose their appetite when they feel sick. If someone stops eating long enough to develop a nutritional deficit, that may weaken the immune system and increase the likelihood of getting sick again," said Ichinohe.

Flu vaccines injected into the upper arm use inactivated virus, but vaccines sprayed into the nose use live attenuated (weakened) virus, researchers said.

"The route of delivery and the type of virus both may change how the immune system responds in high temperatures," said doctoral student

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Tue, February 05 2019. 16:45 IST