The details of his death are not yet known, according to The Hollywood Reporter.
For his role of Freddy Hayes, the owner of a BBQ joint who ends up with a job in the White House, on Netflix's "House of Cards", Cathey won an Emmy in 2015. He was nominated for the award for three straight years.
Most recently, Cathey was seen in the role of Chief Byron Giles on Cinemax series "Outcast" and also played a part in HBO's "The Immortal Life of Henrietta Lacks".
Over the years, Cathey also starred in films such as "Se7en", "American Psycho", "The Machinist", "S.W.A.T" and "Hands of Stone".
He also starred in the Josh Trank-directed reboot of "Fantastic Four". He portrayed the role of Dr. Franklin Storm, the father of Sue and Johnny Storm.
Cathey's "S.W.A.T" co-star Samuel L Jackson paid tributes to the actor on Instagram.
"A Beautiful Talent left us for a more peaceful plane. Reg E. Cathey, true thespian, sage, musician and friend! That band up there is gonna be LIT and the convos just got waaaay heavier!!!" Jackson posted.
Streaming giant Netflix, in a statement, also condoled Cathey's death.
"We are heartbroken by the passing of our friend and House of Cards colleague... Reg was the kindest man, the most giving actor, a true gentleman," it stated.
Cathey was born in Huntsville, Alabama, and spent his childhood in West Germany. He graduated from J.O. Johnson High School, where he acted in plays such as To Kill a Mockingbird.
He later studied theatre at the University of Michigan and the Yale School of Drama.
"The Wire" creator David Simon also paid a tribute to the actor.
"Reg Cathey, 1958-2018. Not only a fine, masterful actor
but simply one of the most delightful human beings with whom I ever shared some long days on set. On wit alone, he could double any man over and leave him thinking. Reg, your memory is a great blessing," Simon tweeted.
Actor Miles Teller, who starred in "Fantastic Four", also condoled Cathey's death and tweeted, "Just read that Reg E. Cathey has passed away. Reg was an incredibly kind and wonderful person with a vibrant love for the arts. He would bring his saxophone to set and serenade everyone at base camp during breaks. Rest In Peace my friend.
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)