Page 203 - Health Medical Pharma
Zydus Cadila receives USFDA approval for Doxycycline Hyclate Delayed-Release Tablets USP
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Dr Reddy's launches Aspirin and Extended-Release Dipyridamole Capsules in U.S.
The Aggrenox brand and generic had U.S. sales of approximately $182 million MAT for the most recent twelve months ending in October 2018 according to IMS Health.
Lupin partners with AbbVie to develop, commercialise novel oncology drug
Drug firms Lupin and AbbVie Monday announced a partnership to develop and commercialise Lupin's novel oncology drug to treat hematological cancers for an upfront fee of USD 30 million and up to USD 947 million on achieving certain milestones. Under the terms of the agreement, AbbVie will pay Lupin an upfront payment of USD 30 million (approx Rs 210 crore) for an exclusive licence to the programme. Upon successful completion of regulatory, development and commercial milestones, Lupin is eligible to receive total milestone payments of up to USD 947 million (approx Rs 6,655 crore), Lupin said in a regulatory filing. Additionally, Lupin will be entitled to receive a double-digit royalty on the sales of the product and will retain commercial rights to the programme in India, the company added. AbbVie has licensed Lupin's MALT1 (Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein1) inhibitor programme. Through this partnership, AbbVie gains exclusive global rights to develop ...
Lupin and AbbVie announce partnership to develop and commercialize Novel Oncology Drug to treat Hemotological Cancers
Under the terms of the agreement, AbbVie will pay Lupin an upfront payment of US$ 30 million for an exclusive license to the program. Upon successful completion of regulatory, development and commercial milestones, Lupin is eligible to receive total milestone payments of up to US$ 947 million. Additionally, Lupin will be entitled to receive a double-digit royalty on the sales of the product and will retain commercial rights to the program in India.
Aurobindo Pharma receives USFDA approval for Vecuronium Bromide Injection
Vecuronium Bromide Injection is used as part of general anesthesia to provide skeletal muscle relaxation during surgery or mechanical ventilation. It is also used to facilitate endotracheal intubation. The approved product has an estimated market size of US$ 11 million for the twelve months ending September 2018 according to IQVIA.
How to be party ready
This party season, steal the limelight with right hair and make up.
Scientists develop electrical protein switches within cell
Scientists in the US have developed electrical protein switches triggered by chemicals that can be used to control the flow of electrons within cells, a development which could facilitate next-generation bioelectronics and lead to the creation of smart pills that release medications only on demand. The scientists at Rice University in Houston used E coli bacteria as a platform to test the protein switches. The metal-containing proteins that are expressed within cells upon the introduction of one chemical are functionally activated by another chemical. If the proteins have been placed in the cell, they can simply be turned on and off. "This is not a metaphor for a switch, it is a literal electrical switch built from a protein," said synthetic biologist Joff Silberg. The proteins could facilitate next-generation bioelectronics, including complete biological circuits within cells that mimic their electronic counterparts. The possible applications include living sensors, electronically ...
Strides receives USFDA approval for Polyethylene Glycol 3350 and Electrolytes for Oral Solution USP
Strides has already garnered an important market share for Polyethylene Glycol 3350, Sodium Chloride, Sodium Bicarbonate and Potassium Chloride for Oral Solution (IMS market share at 22%) and Polyethylene Glycol 3350, Powder for Solution (OTC). With the current approval, Strides now offers a complete range of PEG 3350 Laxatives for the US markets comprising of 3 approved products addressing a combined Rx and OTC opportunity of ~US$ 400 Mn as per IMS and IRi data. The product will be manufactured at flagship facility in Bangalore and will be marketed by Strides Pharma Inc. in the US market.
Researchers uncover genetic causes of eye disease
Hundreds of new genes linked to blindness and other vision disorders have been identified in a screen of mouse strains, according to new research by the University of California, Davis.
Anger, sadness may signal poor health: Study
Negative mood -- such as sadness and anger -- may be a signal of poor health, a study claims. Researchers from Pennsylvania State University in the US found that negative mood measured multiple times a day over time is associated with higher levels of inflammatory biomarkers. This extends prior research showing that clinical depression and hostility are associated with higher inflammation. Inflammation is part of the body's immune response to such things as infections, wounds, and damage to tissues. Chronic inflammation can contribute to numerous diseases and conditions, including cardiovascular disease, diabetes and some cancers. The study, which was published in the journal Brain, Behavior, and Immunity, is the first examination of associations between both momentary and recalled measures of mood or affect with measures of inflammation, said Jennifer Graham-Engeland, an associate professor at Penn State. Participants were asked to recall their feelings over a period of time in ...
Aishwarya Rai celebrates Christmas with children suffering from cancer
Global icon Aishwarya Rai Bachchan celebrated the festival of Christmas at an event hosted by a cancer hospital with kids suffering from the disease.Christmas is considered a festival of spreading love. Keeping this in mind, Cancer Patients and Association organised a Christmas party for 300 cancer-affected children in Wadala area of Mumbai.Aishwarya, who is known for her grace and dedication towards special causes, graced the event. To make the party more pleasing, the 45-year-old sang and danced with the children on 'Kajra Re' and other songs.Looking every bit elegant, Aishwarya donned a floor-length pink and golden Anarkali and completed her look with just the right amount of make-up and accessories.According to reports, Aishwarya adopts 20 children every year and funds all their expenses, including education.
Antibiotic overuse is high in common urology procedures: Study
Antibiotics are being overused in patients undergoing common urological procedures, which exposes them to potential harm including an increased risk of infection by C. difficile bacteria, researchers warned.
AIIMS physiotherapy dept to get a robotic boost
Physiotherapists at AIIMS may soon be providing robot-assisted physical therapy to patients. The physiotherapy department of the institute is soon going to procure this new technology for the early rehabilitation of patients. This announcement was made on Sunday on the concluding day of the seventh International Conference of Physical Therapy AIIMS 2018. Attended by more than 600 delegates from different parts of India and abroad, the two-day conference was inaugurated by Minister of State for Health Ashwini Kumar Choubey on Saturday. The participating dignitaries said the role of physiotherapists would be well defined under Ayushman Bharat as it is an integral part of the government's wellness programme. Choubey said the government will soon pass the Allied and Healthcare Professions Bill, 2018 and appealed the opposition to support it as the act would benefit lakhs of Indians. Nirmal Kumar, organising secretary, said, "With India's ever-growing aging population, it is inevitable ...
Robotic surgeries to begin from January in Delhi's Safdarjung Hospital
Safdarjung Hospital in the national capital is all set to start surgeries using robotic technology in the Urology Department from January 2019 onwards, with the aim to increase the number of treatments in OTs.
Paper sensors for diabetics to monitor blood sugar
Scientists have developed disposable paper-based sensors that can measure glucose concentrations in saliva, paving the way for a pain-free alternative to diabetics for monitoring their blood sugar levels daily. Strips of pH-sensitive paper are commonly used to test whether a liquid is acidic or alkaline. Researchers are now working to apply similar principles to create paper sensors that quickly indicate disease biomarkers. Key to this approach is replacing traditional electronic circuitry in the sensors with low-cost plastics that can be manufactured quickly and in large quantities. A team from the King Abdullah University of Science and Technology (KAUST) in Saudi Arabia used inkjet technology to produce sensors sensitive to small sugar concentrations in biofluids. Utilising a commercial ink made from conducting polymers, the team printed microscale electrode patterns onto glossy paper sheets. They printed a sensing layer containing an enzyme, glucose oxidase, on top of the tiny ...
High blood sugar during pregnancy associated with congenital heart defect
A study has observed that maternal diabetes can lead to fetal heart development of the child.Congenital heart disease (CHD) is the most common birth defect, and even with remarkable advances in care, it remains the leading cause of non-infectious death in infants.CHD is the result of a complicated interplay between genetic and non-genetic, or "environmental," factors acting on the fetus. While the genetic contributors have become increasingly defined, the environmental factors are an important area of investigation. One of those environmental factors is maternal hyperglycemia.A study, published in the Journal of Birth Defects Research, offers a "state of the science" look at the impact of maternal diabetes, and potential gene-environmental influences in that context, on fetal heart development."Many epidemiological studies have demonstrated a strong correlation between maternal diabetes and increased risk of CHD in babies born to affected mothers," said Dr Garg, a researcher. "And ...
Cholesterol-lowering drugs may weaken muscles, nervous system
Statin-induced drugs that are prescribed to individuals with high levels of cholesterol may weaken the patient's muscles and nervous system, a study has observed.According to the research, which has been published in the journal Cell Metabolism, statin reduces the formation of brown adipose tissue which helps to convert sugar and fat into heat. People with brown adipose tissue are better at regulating their body temperature in the winter and are less likely to suffer from excess weight or diabetes.A team of researchers looked into the question of how bad white fat cells, which form the layer of fat under our skin, become good brown fat cells. Having conducted cell culture experiments, they found out that the biochemical pathway responsible for producing cholesterol plays a central role in this transformation. They also discovered that the key molecule regulating the transformation is the metabolite geranylgeranyl pyrophosphate.They also studied positron emission tomography scans of ...
People with schizophrenia experience emotion differently: Study
People with schizophrenia experience emotion through their bodies differently from those who do not suffer from the disorder, a study has found. Researchers from the Vanderbilt University in the US compared individuals with schizophrenia with matched control participants, asking each to fill in a "body map" in a way that correlates to the way they physically experience emotion. They used a computerised coloring task to locate where participants feel sensations when they experience, for example, anger or depression. The outcomes differed radically between groups, with the control group showing distinct maps of sensations for 13 different emotions, indicating specific patterns of increased arousal and decreased energy across the body for each emotion. However, in individuals with schizophrenia, there was an overall reduction of bodily sensation across all emotions. The study also found that individuals with schizophrenia do not differentiate on their body maps for varying emotions. That
Self-powered e-bandage speeds wound healing
Scientists have developed a self-powered bandage that generates an electric field over an injury, dramatically reducing the healing time for skin wounds. Skin has a remarkable ability to heal itself, but in some cases, wounds heal very slowly or not at all, putting a person at risk for chronic pain, infection and scarring. Chronic skin wounds include diabetic foot ulcers, venous ulcers and non-healing surgical wounds. Doctors have tried various approaches to help chronic wounds heal, including bandaging, dressing, exposure to oxygen and growth-factor therapy, but they often show limited effectiveness. Researchers from University of Wisconsin in the US and University of Electronic Science and Technology of China wanted to develop a flexible, self-powered bandage that could convert skin movements into a therapeutic electric field. They tested the bandage on rats. To power their e-bandage, the team made a wearable nanogenerator by overlapping sheets of polytetrafluoroethylene (PTFE), ...
How people with schizophrenia experience emotions
A recent study - with the help of 'body maps' - showed that people with schizophrenia experience emotion differently from others.The findings of the Vanderbilt University researchers have been published in the journal Schizophrenia Bulletin.Sohee Park and Lenie J. Torregrossa compared individuals with schizophrenia with matched control participants, asking each to fill in a "body map" in a way that correlates to the way they physically experience emotion. They used a computerised colouring task to locate where participants feel sensations when they experience, for example, anger or depression.The outcomes differed radically between groups, with the control group showing distinct maps of sensations for 13 different emotions, indicating specific patterns of increased arousal and decreased energy across the body for each emotion. However, in individuals with schizophrenia, there was an overall reduction of bodily sensation across all emotions.The study also found that individuals with ...