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Experts discover genetic cause of rare high blood pressure syndrome

ANI  |  Washington D.C. [U.S.A.] 

A new study has discovered the genetic cause of a rare high pressure syndrome.

and a team of scientists from the and have now identified a new disease gene. The study focused on a particular and very rare form of high pressure, known as familial hyper aldosteronism type II.

This causes the adrenal gland to produce high level of aldosterone - a hormone that regulates the water and salt conservation in the kidneys. Excess of this hormone in the body shoots up the pressure.

According to the research, more than a billion people worldwide suffer from or Such a condition, if prolonged, damages blood vessels, which can result in damage to the heart, the kidneys, and the brain.

Possible consequences may include heart attack, and Besides obesity, salt consumption and alcohol intake, genetic factors play an important role in the development of

In some rare cases, is caused by mutations within single genes. These genes play important roles in blood pressure determination. These mutations typically cause early-onset hypertension, even in young children and adolescents.

Type II of was first described in an Australian family 25 years ago. The research team investigated this family along with other patients suffering from in childhood and adolescence.

A total of eight families, including the large Australian family, showed mutations in a gene that had not previously been associated with blood pressure regulation. The CLCN2 gene carries information for building a channel in the cell membrane through which chloride ions can pass.

In specific cells of the adrenal gland, these chloride channels regulate membrane voltage and aldosterone production. Gene mutations in patients with cause changes in the membrane voltage and result in the overproduction of aldosterone, which raises blood pressure.

The findings from this study have been published in the scientific journal

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Tue, February 06 2018. 12:25 IST