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This 'selfish' gene may prevent heart disease

IANS  |  New York 

Scientists have identified a "selfish" gene that can potentially remove from blood vessels and help prevent

The gene, called MeXis, acts within key cells inside clogged arteries to help remove excess from blood vessels.

In mice, MeXis was found to control the expression of a protein that pumps out of cells in the artery wall, said researchers from the (UCLA).

In the study, published in the journal Nature Medicine, researchers found that mice lacking MeXis had almost twice as many blockages in their blood vessels compared to mice with normal MeXis levels.

In addition, boosting MeXis levels made cells more effective at removing excess cholesterol.

MeXis is an example of a "selfish" gene, one that is presumed to have no function because it does not make a

However, new studies have suggested that these so-called "unhelpful" genes can actually perform important biological functions without making proteins and also produce a special class of molecules called long non-coding RNAs, or lncRNAs.

"The idea that lncRNAs are directly involved in very common ailments such as plaque build-up within arteries offers new ways of thinking about how to treat and diagnose disease," Tamer Sallam, at the UCLA.

"There is likely a good reason why genes that make RNAs rather than proteins exist. A key question for us moving forward is how they may be involved in and disease," Sallam added.

Considering many genes like MeXis have completely unknown functions, the study suggests that further exploring how other long non-coding RNAs act will lead to exciting insights into both normal physiology and disease, the researchers said.

--IANS

rt/and/in/bg

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Wed, February 14 2018. 15:16 IST
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