Another six passengers in the ill-fated jeep sustained injuries and have been hospitalised, police said.
The victims, all related to each other, were identified as villagers of Ramavaram in Gadwal district of neighbouring Telangana state.
They were returing home after attending a marriage when the mishap took place.
Some passengers in the bus received minor injuries, police said.
Police said the luxury bus, proceeding from Hyderabad to Bengaluru, collided with the jeep that swerved into the other side of the highway in a bid to avoid a two-wheeler.
As the bus was cruising at high speed, the impact of the collision was heavy and left 10 dead on the spot, police said.
"The jeep was badly mangled and many other passengers were trapped inside.We have pulled out four injured passengers so far and shifted them to the government hospital in Kurnool for treatment," a senior police official said over phone.
Police fear the toll could increase.
He asked the SP to ensure better medical care to the injured passengers.
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)