You are here: Home » Companies » News
Business Standard

Glenmark to conduct clinical trials of its molecule on cancer patients

Glenmark Pharmaceuticals on Monday said its unit has received approval from the DCGI to conduct phase 1 clinical trials of its novel molecule on patients with advanced solid tumors.

Topics
Glenmark Pharmaceuticals | cancer patient | clinical trials

Press Trust of India  |  New Delhi 

glenmark
glenmark

on Monday said its unit has received approval from the Drug Controller General of India (DCGI) to conduct phase 1 of its novel molecule on patients with advanced solid tumors.

Glenmark Specialty SA has received approval from the DCGI to conduct a Phase 1 clinical trial of its novel small molecule, GRC 54276, a hematopoietic progenitor kinase 1 (HPK1) inhibitor.

GRC 54276 is one of the many novel molecules from Glenmark's Innovative Medicines Group specialising in the development of novel molecular entities for critical unmet medical needs.

The Mumbai-based drug major said, GRC 54276 has shown tumor cell killing ability in preclinical studies as a single agent and as well in combination with checkpoint inhibitors, making it a high-priority target in immuno-oncology.

The study will evaluate the safety and tolerability of GRC 54276 as a monotherapy, and also in combination with checkpoint inhibitors in patients with advanced solid tumors and Hodgkin's lymphoma, it added.

The company said it will initiate Phase 1 clinical trial in India by June 2022, and also plans to file an IND (Investigational New Drug) application in the US and clinical trial applications in Europe to kick-off a fully global clinical study programme.

"We are delighted that our first novel molecule from the newly formed 'Innovative Medicines Group' within Glenmark has received approval from India's drug regulator to initiate a Phase 1 clinical trial.

"This reinforces Glenmark's growing capabilities of innovative clinical research and is a step closer in providing holistic solutions for cancer treatment," Chairman & Managing Director Glenn Saldanha noted.

Glenmark has a presence across specialty, generics and OTC businesses. It focuses on the key therapeutic areas of respiratory, dermatology and oncology. The company has ten manufacturing facilities spread across four continents and operations in over 80 countries.

(Only the headline and picture of this report may have been reworked by the Business Standard staff; the rest of the content is auto-generated from a syndicated feed.)

Dear Reader,


Business Standard has always strived hard to provide up-to-date information and commentary on developments that are of interest to you and have wider political and economic implications for the country and the world. Your encouragement and constant feedback on how to improve our offering have only made our resolve and commitment to these ideals stronger. Even during these difficult times arising out of Covid-19, we continue to remain committed to keeping you informed and updated with credible news, authoritative views and incisive commentary on topical issues of relevance.
We, however, have a request.

As we battle the economic impact of the pandemic, we need your support even more, so that we can continue to offer you more quality content. Our subscription model has seen an encouraging response from many of you, who have subscribed to our online content. More subscription to our online content can only help us achieve the goals of offering you even better and more relevant content. We believe in free, fair and credible journalism. Your support through more subscriptions can help us practise the journalism to which we are committed.

Support quality journalism and subscribe to Business Standard.

Digital Editor

First Published: Mon, April 11 2022. 11:20 IST
RECOMMENDED FOR YOU
.