Kava, a medicinal South Pacific plant, can significantly reduce the symptoms of people suffering anxiety, according to the first ever completed clinical study on the plant.
The study led by the University of Melbourne revealed Kava could be an alternative treatment to pharmaceutical products for people who suffer from Generalised Anxiety Disorders (GAD).
Lead researcher, Dr Jerome Sarris from Department of Psychiatry at the University of Melbourne, said GAD is a complex condition that significantly affected people's day-to-day lives.
Existing medications have a modest clinical effect and new effective options were needed for patients with anxiety.
"Based on previous work we have recognised that plant based medicines may be a viable treatment for patients with chronic anxiety," he said.
"In this study we've been able to show that Kava offers a potential natural alternative for the treatment of chronic clinical anxiety. Unlike some other options it has less risk of dependency and less potential for side effects," he said.
The study also found that people's genetic differences (polymorphisms) of certain neurobiological mechanisms called GABA transporters, may modify their response to Kava.
"If this finding is replicated, it may pave the way for simple genetic tests to determine which people may be likely to have a beneficial anxiety-reducing effect from taking Kava," Sarris said.
During the eight-week study, 75 patients with clinically diagnosed GAD were given Kava or placebo, and anxiety levels were regularly assessed.
Results showed a significant reduction in anxiety for the Kava group compared to the placebo group at the end of the study.
In participants diagnosed with moderate to severe GAD, Kava had an even greater effect in reducing anxiety. Following the completion of the controlled phase, 26 per cent of the Kava group were classified as in remission from their symptoms compared to six per cent of the placebo group.
Participants in the Kava group were given tablets twice per day consisting of water-soluble extracted Kava (peeled rootstock) for a total dose of 120mg of kavalactones for the first three-week controlled phase.
In cases of non-response this was increased to a double-dose twice per day for the second three-week controlled phase. Participants in the placebo group took matching dummy tablets in the same manner.
Kava was also well tolerated. Results showed no significant differences across the two groups for liver function which had previously been a concern for Kava's medicinal use.
The study was published in the Journal of Clinical Psychopharmacology.
