Page 119 - Health Medical Pharma

Dietary changes help reduce inflammatory bowel disease in mice, claims study

A recent study conducted on mice has found that dietary modification helps in treating Inflammatory bowel disease (IBD).University of Southern California researchers published a paper in the Cell Reports journal proving that changing the diet to a fasting-mimicking diet (FMD) where the mice were only fed plant-based foods over a period of several days to trick the body into entering a period of fasting which in turn changed the gut microbiota that reduced the IBD pathology.FMD has previously shown a reduction of the symptoms of several chronic illnesses, like multiple sclerosis and diabetes.During the study, researchers induced IBD symptoms and pathology in mice by feeding them dextran sodium sulphate (DSS) which causes gut inflammation in mice. The mice after this received multiple FMD cycles involving vegan food. Another group of mice were infected by DSS but underwent water only fasting. Mice that received FMD showed reduced symptoms, increased stem cell numbers and reversed ...

Glenmark gets USFDA nod for generic version of acne treatment gel

Glenmark Pharmaceuticals Friday said it has received final approval from the US health regulator for its generic version of BenzaClin gel used in treatment of acne. The approval granted to Glenmark Pharmaceuticals Inc, USA (Glenmark) by the United States Food & Drug Administration (USFDA) is for for Clindamycin and Benzoyl Peroxide Gel, 1 per cent|5 per cent, a generic version of BenzaClin1 Gel, 1 per cent|5 per cent, of Valeant Bermuda, the company said in a statement. Citing IQVIATM sales data, Glenmark said BenzaClin Gel, 1 per cent |5 per cent had sales of USD 99.4 million in the 12-month period ended January 2019. Glenmark's current portfolio consists of 151 products authorised for distribution in the US with 53 ANDA's (abbreviated new drug applications) pending approval with the USFDA.

Glenmark Pharmaceuticals Receives ANDA Approval for Clindamycin and Benzoyl Peroxide Gel, 1%|5%

/ -- Glenmark Pharmaceuticals Inc., USA (Glenmark) has been granted final approval by the United States Food & Drug Administration (U.S. FDA) for Clindamycin and Benzoyl Peroxide Gel, 1%|5%, a generic version of BenzaClin1 Gel, 1%|5%, of Valeant Bermuda. (Logo: https://mma.prnewswire.com/media/451507/PRNE_Glenmark_Logo.jpg ) According to IQVIA sales data for the 12 month period ending January 2019, the BenzaClin Gel, 1%|5% market2 achieved annual sales of approximately $99.4 million*. Glenmark's current portfolio consists of 151 products authorized for distribution in the U.S. marketplace and 53 ANDA's pending approval with the U.S. FDA. In addition to these internal filings, Glenmark continues to identify and explore external development partnerships to supplement and accelerate the growth of its existing pipeline and portfolio. 1All brand names and trademarks are the property of their respective owners. 2Market includes brand and all available therapeutic equivalents *IQVIATM ..

Early menopause in smokers raises bladder cancer risk

Experiencing menopause before the age of 45 is associated with a higher risk of bladder cancer particularly among smokers, says a new study.

Cong may include Healthcare Act promise in manifesto: Rahul

Congress president Rahul Gnadhi Friday said his party was looking at including the promise of Healthcare Act in its manifesto for the April-May Lok Sabha polls. He said it was part of the Congress' commitment to ensure everybody has access to quality healthcare. The Congress chief said his party wanted to increase health expenditure to 3 per cent of the country's Gross Domestic Product (GDP) and also increase the number of trained medical professionals. Gandhi was speaking to medical professionals here at a programme organised by an NGO.

New approach may help fight TB effectively: Study

Structures released by tuberculosis-infected cells may be used in tandem with antibiotics to boost the body's immune system, helping fight off the disease, according to a study. The study, published in the journal EMBO Reports, found that the structures, called extracellular vesicles (EVs), contain Mycobacterium tuberculosis RNA -- a molecule essential in various biological roles -- and transfer it to other cells. This starts a built-in weapon system against the disease in the form of an immune response, said researchers from the University of Notre Dame in the US. Though extracellular vesicles containing RNA from viruses had been discovered years ago, the researchers recently discovered RNA from bacteria -- Mycobacterium tuberculosis -- in EVs. This discovery led to experiments to determine how the bacteria's RNA was affecting the "target" cell, including cells infected by M tuberculosis. A key discovery hinges on macrophages, which are cells of the immune system, researchers ...

First in Asia, Aster CMI doctors rescue teen suffering from rarest of the rare genetic disease

Doctors give a new lease of life to teen through a bone marrow transplant. Till now, less than 10 such cases have been successfully transplanted in the world.The hospital highlights the need to increase awareness of Immune Deficiency. Aster CMI's Pediatric Immunology Department recognized as Foundation for Primary Immunodeficiency Diseases (FPID) centre of excellence.Ciara (name changed), a 13-year-old-girl from Mauritius, suffering from rarest of the rare Complement Deficiency genetic disease, C1q deficiency since the age of 2, became the first teen in Asia suffering from this complex condition to receive a bone marrow transplant. Thanks to the team of efficient doctors at Aster CMI Hospital, Bengaluru for granting her a new lease of life. Ciara was suffering from repeated skin rashes and kidney ailments for over a decade and also developed difficulty in walking and stiffening of lower limbs. Until the transplant, Ciara was on multiple immune-suppressants to control the autoimmune ...

Anti-mosquito drug can reduce malaria in children: Lancet

A mosquito-killing drug can reduce malaria incidence in young children by 20 per cent, results of trial has showed.

Delhi woman undergoes third kidney transplant

A 45-year-old woman from Delhi underwent a record third kidney transplant at a hospital here, proving true the adage 'No matter how hard life is, don't lose hope'. Ekta Kalra has undergone three kidney transplants since 2001, the latest being in November 2018. According to doctors performing multiple transplants in a patient, the task is very challenging as with every transplant, the surgery gets more and more dangerous as the potential for complications increases. It was Kalra's third transplant and the patient was much older, making the potential for complications far more, Sandeep Guleria, senior consultant, General Surgery, GI Surgery and transplantation at Indraprastha Apollo Hospitals, said. In the case of Kalra, it was her husband who donated his kidney to save her life this time. Even though they were ABO incompatible, which means that their blood group did not match, the doctors took the challenge and performed the highly complicated transplant successfully. A routine ...

Appointment of 437 medical officers cancelled for failing to join duties

The Jammu and Kashmir administration Thursday ordered cancellation of appointment of 437 medical officers, who had been recently appointed by the Health and Medical Education Department, for failing in joining their duties, an official spokesman said. "The appointments in respect of 437 medical officers appointed vide a government order on January 14 shall be deemed to have been cancelled ab-initio," he said. The spokesman said the Directorate of Health Services, Kashmir and Jammu, have furnished the information and particulars of the medical officers who did not joined their respective place of postings. Earlier on the recommendations of divisional commissioner, Kashmir, the date of joining for medical officers was extended by the department due to inclement weather conditions prevailing in the state up to February 26. However, it was mentioned that in case they fail to join at their respective place of postings within stipulated period of time their appointments would be deemed to ..

Lingayat spiritual leader Mathe Mahadevi dead

Lingayat leader Mathe Mahadevi passed away at a private hospital here on Thursday due to cardiac arrest, a statement from the hospital said.

Mystery infections traced to blood-shedding religious ritual

Add self-flagellation to the list of ways to get a dangerous viral blood infection. Researchers said Wednesday that they were initially puzzled how 10 British men had become infected with a little-known virus, because the men hadn't taken risks usually associated with the infection. But then investigators learned they had participated in blood-shedding religious rituals cutting or whipping themselves in Iraq, Pakistan, India and the United Kingdom. "There have been suggestions that you might spread infections through this route, but it has never been described before" in a published medical study, said Dr. Divya Dhasmana of St. Mary's Hospital in London. She is one of the authors of the study released Wednesday in a journal published by the US Centers for Disease Control and Prevention. The men were infected with human T-cell leukemia virus type 1. Most people infected with the virus never develop symptoms, but some develop terrible illnesses, like a deadly blood cancer or a ...

Prominent Lingayat seer Maate Mahadevi passes away

Maate Mahadevi, a prominent woman pontiff of Lingayat community and seer of the 'Basava DharmaPeetha', died at a private hospital here Thursday following cardiacarrest, doctors said. She was at the forefront of the movement demanding separate religion status for the Lingayat community that erupted inthe state in 2017-18. Manipal Hospitals Chairman Dr H Sudarshan Ballal said Maate Mahadevi, 74, was critically ill and admitted on March 8 at Manipal Hospitals. She died at 4.45 pm, he added. She had prolonged renal illness and wason advanced life support system since admission, Ballal said in a statement. "She required multiple organ and life support including ventilation, BP support, and dialysis. Her condition was extremely critical and she was receiving broad-spectrum antibiotics for sepsis," he said. Installed as 'Jagadguru' in the 1970s, Maate Mahadevi launched several educational and religious institutions and published several books. The last rites will be conducted ..

Vit B in pregnancy prevents brain ailments in baby

Besides flu vaccines, maternal intake of a vitamin B nutrient can prevent babies from brain disorders caused by cold or flu in pregnancy, say researchers.

Taking too much vitamin D may cloud its benefits

While vitamin D comes with a lot of benefits, one should know the right amount of intake of vitamin D. According to a recent study, obese older women, who take more than three times the recommended daily dose of vitamin D showed improvements in memory and learning but also had slower reaction times. The researchers hypothesized that slower reaction times may increase the risk of falling among older people. The results of the study were published in 'Journals of GerontologyThe researchers found that memory and learning improved in the group that took 2,000 IU per day, but not in the group that took the higher dosage. Meanwhile, the women's reaction time showed a trend to be slower at 2,000 IU daily and was significantly slower at the higher dosage. "The slower reaction time may have other negative outcomes such as potentially increasing the risk of falling and fractures," said senior study author Sue Shapses."This is possible since other researchers have found that vitamin D ...

A cup of tea - with a twist

In the fast-paced urban environment where there's a marked change in millennials' preferences, the perception of tea is fast shifting from being a commodity into a lifestyle product, say experts.

Key to growing human blood vessels found

Researchers have discovered an ingredient vital for proper blood vessel formation that may help develop better treatments for a host of serious conditions ranging from diabetes to heart attacks and strokes. Scientists seeking to grow blood vessels have focused almost exclusively on growing only the inner layer of blood vessels, which are made up of endothelial cells. The hope was that these endothelial cells would then recruit any other cell types needed to form a complete, functional blood vessel, according to the study published in the journal Nature Communications. Researchers led by the University of Virginia School of Medicine in the US determined that those vessels can develop properly only if they are grown in conjunction with another cell type, known as perivascular cells, including smooth muscle cells and pericytes. The researchers liken these perivascular cells to the outer support layers of a rubber hose or on automobile tires, without which they burst or leak. "Most of the

USFDA issues import alert on Hospira's Chennai plant

The USFDA has imposed Import Alert on the drugs being manufactured at a facility owned by Hospira Healthcare India, a Pfizer company, in Tamil Nadu after the regulator found lapses with regard to good manufacturing practice (CGMP) regulations during an inspection. "FDA placed your firm on Import Alert 66-40 on August 1, 2018. Until you correct all violations completely and we confirm your compliance with CGMP, FDA may withhold approval of any new applications or supplements listing your firm as a drug manufacturer," FDA said in a letter to the drug maker. The US Food and Drug Aadministration (USFDA) conducted inspection from March 27 to April 3, 2018. "The critical data integrity breaches identified in our inspection also raise serious concerns regarding the validity of all results reported by your quality control laboratory. We acknowledge your decision during the inspection to suspend release of drug products until the data integrity issues are thoroughly ...

Green tea helps combat obesity, inflammation: Study

Want to cut that extra flab? Drinking green tea can help reduce obesity as well as inflammation in the gut, finds a study.

Soon, nano-bots may help diagnose, treat cancer

Scientists have designed a nanorobotics system that may be used to study the properties of cancer, and help improve diagnosis and treatment of the deadly disease. The nano-bot, described in the journal Science Robotics, is a set of magnetic 'tweezers' that can position a nano-scale bead inside a human cell in three dimensions with unprecedented precision. "Optical tweezers -- using lasers to probe cells -- is a popular approach," said Xian Wang, a PhD candidate at the University of Toronto in Canada. The technology was honoured with 2018 Nobel Prize in Physics, but Wang said the force that it can generate is not large enough for mechanical manipulation and measurement he wanted to do. The system Wang designed uses six magnetic coils placed in different planes around a microscope coverslip seeded with live cancer cells. A magnetic iron bead about 700 nanometres in diameter -- about 100 times smaller than the thickness of a human hair -- is placed on the coverslip, where the cancer ...