Page 328 - Health Medical Pharma
Too much sitting can lead to health risks!
Did you know prolonged sedentary time could lead to health risks? Sitting for too many hours per day or sitting without a break is known to harm your body, a new study reveals.While the evidence on the adverse effects of prolonged sedentary time continues to increase, further studies are needed to determine the most effective and practical interventions for reducing habitual sitting.Nurses and other health care professionals now have a new priority: educating patients about the health risks of prolonged sedentary time and making suggestions to reduce and interrupt sitting times."Nurses have a pivotal role to play in increasing public awareness about the potential adverse effects of high-volume and prolonged uninterrupted sitting," said study author and Dr Linda Eanes.Increased health risks have been reported both for high-volume sitting, such as sitting for seven or more hours per day, and for prolonged uninterrupted sitting, such as sitting for 30 minutes or longer without a break. ..
Liver disease drug may help treat Alzheimer's: Study
A drug which has been used to treat liver disease for decades could help restore cells damaged by Alzheimer's, a study claims. Researchers from the University of Sheffield in the UK discovered the drug ursodeoxycholic acid (UDCA) improves mitochondrial dysfunction -- which is known to be a causative factor for both sporadic and familial Alzheimer's disease. Mitochondria play a pivotal role in both neuronal cell survival and death as they regulate energy metabolism and cell death pathways acting as a cell's battery, according to the research published in the Journal of Molecular Biology. Mitochondrial abnormalities have been identified in many cell types in Alzheimer's disease, with deficits occurring before the development of the classical pathological aggregations, researchers said. The energy changes have been found in many different cells from people with Alzheimer's, they said. "For the first time in actual Alzheimer's patient tissue this study has shown that the drug UDCA acid ...
Structure of FAT10 protein analyzed!
A new study has identified the existence of inefficient FAT10 system- a small protein with a huge effect.Its attachment to a target protein is a signal for its degradation. FAT10 is a marking system for degradation that seems to be inefficient. In contrast to its biological competitor, ubiquitin, which is recycled, FAT10 is degraded along with its target protein which appears wasteful at first glance.A team of researchers at the University of Konstanz analyzed the high-resolution structure of the protein FAT10. The team developed a molecular technique to produce stable and highly-concentrated FAT10 with a high degree of purity. As a consequence, the researchers could carry out a structural analysis of FAT10 via x-ray crystallography and magnetic resonance spectroscopy.In contrast to ubiquitin with one domain, FAT10 has two domains, i.e. folds that enable the proteins to function. The team discovered that both domains are connected by a flexible linker and their folding is ...
Jubilant Cadista Pharma recalls over 46K bottles of hypertension drug from US
Jubilant Cadista Pharmaceuticals Inc is recalling over 46,000 bottles of Valsartan tablets manufactured by Jubilant Generics Ltd at its Roorkee plant from the American market, the latest Enforcement Report of the US health regulator has said. Valsartan tablets are used for treatment of hypertension and heart failure. The company is recalling 10,577 bottles of Valsartan tablets USP in the strength of 40 mg, 9,552 bottles of the 80 mg tablets, 18,947 bottles of 160 mg tablets and 7,048 bottles of 320 mg tablets, the report added. The tablets are being recalled on account of "Incorrect/Undeclared excipient: There is a potential an incorrect grade of excipient was used during manufacturing," it added. The voluntary, ongoing recall is a class III recall, the report by the United States Food and Drug Administration (USFDA) said. The product was distributed throughout the United States to wholesalers and retailers, it added. As per USFDA, a class III recall is initiated in a situation, "in ..
Your genetic profile decides severity of asthma symptoms
Turns out, asthma patients with a specific genetic profile exhibit more intense symptoms of asthma following exposure to vehicular pollution.According to researchers at the National Institutes of Health, asthma patients who lack this specific genetic profile do not have the same sensitivity to vehicular pollution and do not experience worse asthma symptoms.The scientists stated that the results were based on genetic variation, the subtle differences in DNA that make each person unique. They further added that to understand the concept, one should think of human genes, which are made up of DNA base pairs A, C, G, and T, as written instructions for making proteins."All humans have the same genes, in other words, the same basic instructions, but in some people, one DNA base pair has been changed. This common type of genetic variation is called a single nucleotide polymorphism or SNP, and it can alter the way proteins are made and make individuals more or less prone to illness," said ...
Microwave weapon suspected in mystery attacks on US diplomats: report
Doctors and scientists increasingly suspect attacks with unconventional microwave weapons as the cause of the mysterious ailments that have stricken more than three dozen American diplomats and their families in Cuba and China, The New York Times reported Sunday. The victims reported hearing intense high-pitched sounds in their hotel rooms or homes followed by symptoms that included nausea, severe headaches, fatigue, dizziness, sleep problems and hearing loss. A medical team that examined 21 of those affected in Cuba did not mention microwave weapons as a cause in a study published in March in the Journal of the American Medical Association. But its lead author, Douglas Smith, the director of the Center for Brain Injury and Repair at the University of Pennsylvania, told the Times that microwave weapons are now considered a main suspect and that the team is increasingly sure the diplomats suffered brain injury. "Everybody was relatively skeptical at first," he was quoted as saying, ...
More than 300,000 people suffer from kidney ailments: Expert
More than 300,000 people are suffering from end-stage kidney ailments and despite that only 10,000 transplantations are taking place, nephrologist and renal transplant physician Raka Kasuhal said on Sunday.
ASD may increase depression risk
People with autism spectrum disorders (ASD) -- especially without intellectual disability -- may have a greater risk of depression in their young adulthood, a new study, led by an Indian-origin researcher, suggests.
Chinese medicine ingredient may help treat obesity
A plant-derived substance widely used in traditional Chinese medicine can 'switch on' the feeling of fullness and help people lose weight, scientists have found. The study, published in the journal Diabetes, showed that the substance called Celastrol could offer a new option for the treatment of obesity. According to expert guidelines for the prevention and treatment of obesity, patients should aim to lose between five and ten per cent of their body weight per year depending on their body mass index. However, despite the huge amount of dietary and lifestyle choices available, only few people reach their weight loss goal. "Yet, breaking through this 'magical barrier' is so important, as it leads to an improvement in metabolism and accompanying metabolic diseases such as type 2 diabetes," said Paul Pfluger, from the Helmholtz Zentrum Munchen (Helmholtz Center Munich) in Germany. The researchers were able to prove that Celastrol activates specific satiety centres in the brain which play .
Chinese medicine ingredient may help reduce obesity
A herbal ingredient used in traditional Chinese medicines may help you to reduce your body weight, a new study has found.
AI system helps successfully treat cancer patient
In a first, scientists have used a powerful artificial intelligence (AI) platform, to successfully treat a patient with advanced cancer, completely halting disease progression. The research team successfully utilised a platform called CURATE.AI to continuously identify the optimal doses of each drug to result in a durable response, allowing the patient to resume a completely normal and active lifestyle. The patient with metastatic castration-resistant prostate cancer (MCRPC) was given a novel drug combination consisting of investigational drug ZEN-3694 and enzalutamide, an approved prostate cancer drug. "Dynamic dosing in cancer therapy is not commonly used. In fact, drug dosing changes in oncology are typically performed only to reduce toxicity," said Dean Ho, from National University of Singapore (NUS). "CURATE.AI uniquely modifies drug dosing to increase efficacy. Our clinical study has shown that dosing can profoundly affect the efficacy and safety of treatment," said Ho, who led .
Ronnie Wood's wife wants more kids
Ronnie Woods wife Sally says they may have more children now that the rock legend has won his cancer fight.
AI technique used to treat metastatic cancer patient: Study
Singaporean researchers have harnessed the power of artificial intelligence (AI) to successfully treat a patient with advanced cancer, completely halting disease progression.
Study uncovers method to treat cocaine abuse
According to a study, bile acids - which are critical for digestion and absorption of fats and fat-soluble vitamins in the small intestine - could reduce the desire for cocaine.Researchers at Vanderbilt University Medical Center and the University of Alabama at Birmingham suggest that targeting bile acid signaling in the brain may be a novel way to treat cocaine abuse.Vanderbilt investigators Charles (Robb) Flynn, and Naji Abumrad, John L. Sawyers Professor of Surgical Sciences, have long studied the metabolic changes associated with bariatric surgery for weight loss."Surgical patients experience dramatic changes in glucose regulation and in taste preferences and food cravings while they are still in the recovery room," Flynn said."These surgeries are doing something more than we understand. We wondered if elevated serum bile acids, a hallmark of bariatric surgery, were affecting the reward centers of the brain to blunt the pleasure of eating high-fat foods," he said.If the surgery ...
Helping people in need may make you better parents: Study
Providing social support specifically to people in need activates regions of the brain involved in parental care, scientists say. The findings may help researchers understand the positive health effects of social ties. By comparison, providing "untargeted" support such as giving to charity does not have the same neurobiological effects, according to the study published in the Psychosomatic Medicine: Journal of Biobehavioral Medicine. Researchers from University of Pittsburgh in the US performed a pair of experiments to evaluate brain responses to providing different kinds of social support. In the first study, 45 volunteers performed a "giving support" task where they had a chance to win rewards for someone close to them who needed money (targeted support), for charity (untargeted support), or for themselves. As predicted, participants felt more socially connected, and felt that their support was more effective, when giving targeted social support. The subjects then underwent an ...
Here's how genetics, pollution severe asthma symptoms
A recent research has found how genetics and pollution drive severity of asthma symptoms.Researchers at the National Institutes of Health found that asthma patients, with a specific genetic profile, exhibit more intense symptoms following exposure to traffic pollution.The research team also found that asthma patients that lack this genetic profile do not have the same sensitivity to traffic pollution and do not experience severe asthma symptoms.Co-lead author Shepherd Schurman stated that the results were based on genetic variation, the subtle differences in DNA that make each person unique. He further said that to understand the concept, one should think of human genes, which are made up of DNA base pairs A, C, G, and T, as written instructions for making proteins."All humans have the same genes, in other words, the same basic instructions, but in some people, one DNA base pair has been changed," Schurman said. "This common type of genetic variation is called a single nucleotide ...
High BMI in early life linked to asthma risk later: Study
The growth of children in the first three years of their life affects the development of their lungs and the risk of asthma at 10 years of age, says a study.
McCain ends 81-year journey with burial at Naval Academy
John McCain is being laid to rest at the US Naval Academy in Annapolis, Maryland. The private burial Sunday next to Adm Chuck Larson brings to a close the six-term senator's cross-country farewell after he died of brain cancer August 25 in Arizona. The procession was carefully designed by McCain as a final call to arms to a nation he feared was at risk of losing its civility and sense of shared purpose. To illustrate the warning, McCain asked former Presidents Barack Obama and George W Bush to eulogize him at Washington National Cathedral. The service Saturday was a rebuke of President Donald Trump's divisive politics. Trump had mocked McCain for getting captured in Vietnam and was not invited to any events. The president spent the day tweeting and golfing.
Ex-Himachal CM hospitalised
Former Himachal Pradesh Chief Minister and Congress leader Virbhadra Singh was hospitalised following uneasiness in the chest, doctors said on Sunday.
Sir Ganga Ram hospital doctor chosen for BC Roy award
A nephrologist at the city-based Sir Ganga Ram Hospital has been chosen for the prestigious B C Roy National Award, hospital authorities said Saturday. "Dr A K Bhalla, Co-chairperson, Department of Nephrology, Sir Ganga Ram Hospital (SGRH), has been selected in the category -- to recognise the best talents in encouraging the development of specialities in different branches of medicine (Nephrology)," a spokesperson of the hospital said. Bhalla has been working at the SGRH for the last30 years as a consultant nephrologist and has trained more than 50 students in nephrology, he said. "He is pioneer in starting peritoneal dialysis in India and also ABO incompatible kidney transplants," the spokesperson said. The Bidhan Chandra Roy Award was instituted in 1976 in the memory of renowned physician and freedom fighter B C Roy by Medical Council of India.