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Gut microbes could predict risk of hospitalisation with cirrhosis: Research

Relative abundances of pathogenic and non-pathogenic bacteria in the gut microbiome would be accurate predictors of hospitalisation

Press Trust of India  |  Washington 

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The - a collection of bacteria and other microbes in the gut - could be a highly accurate predictor of hospitalisations for patients with cirrhosis, according to scientists, including one of Indian origin.

The research, published in the journal JCI Insight, determined that analysis of microbial DNA and microbial RNA could be used alongside current clinical methods to more accurately predict 90-day hospitalisations.

Microbial DNA analysis identifies live and dead bacterial species, while microbial RNA analysis identifies the most metabolically active microbial species.

"The hospitalisations that take place with are exorbitantly expensive. Anything that helps us predict the likelihood of is better than the status quo," said Jasmohan Bajaj from Virginia Commonwealth University in the US.

The researchers theorised that relative abundances of pathogenic and non-in the would be accurate predictors of because of their link with inflammation, which often leads to infection.

"One of the major sources of inflammation in patients with or individuals who are obese is pathogenic bacteria, so, we began looking at gut microbes," Bajaj said.

"People with who are hospitalised tend to get a very big inflammatory surge in their body because of infections and other organ failures," he said.

The researchers conducted a trial of patients with cirrhosis. They were classified according to cirrhosis-related complications, such as renal dysfunction and infection.

Both DNA and RNA analysis were found to be equally effective at predicting when combined with the standard predictive

They also were more effective than the standard predictive score alone. The researchers also found that DNA and RNA analysis identified similar beneficial bacteria but differed in the identified in all patient groups tested.

First Published: Sat, March 31 2018. 23:38 IST