Argentine striker Sergio Aguero has been ruled out for a month with a hamstring injury suffered in their 0-2 home defeat against Ecuador.
The 27-year-old was stretchered off after just 22 minutes on Thursday.
"I think I'll be a month without playing," Aguero was quoted as saying by bbc.com on Saturday.
Aguero, who plays his club football for Manchester City, may miss four English Premier League games as a result of his latest injury. City has only just Wilfried Bony as a recognised central striker, in the absence of Aguero.
