Born in the Romanian port city of Galati on November 10, 1887, Zamfirescu passed school with high marks from the Central School of Girls in Bucharest, and earned a baccalaureate from Mihai Viteazul High School.
Instead, she went to the Royal Technical University of Charlottenburg, now known as the Technical University of Berlin, where she studied mechanical engineering.
There, too, life was not a bed of roses. One of her deans remarked she would be better off focusing on "Kirche, kinder, and kuche" (Church, children, and cooking).
But young Zamfirescu persisted for three years to earn her degree and become one of the first woman engineers in the world.
In her 86 years of life, Zamfirescu carved herself a spot in a male-dominated field, led geology labs, and studied Romanian mineral resources.
She oversaw numerous economic studies analysing Romania's supply of natural resources like coal, shale, natural gas, chromium, bauxite and copper, Google said.
She introduced new methods and analysis techniques to study minerals and substances such as water, coal, and oil and is remembered as a dedicated engineer who worked long hours from morning to evening.
Zamfirescu kept working past retirement age and didn't fully retire until the age of 75 years old after a four-decade career.
She was known for paying special attention to the training of staff and spending long hours mentoring young chemists.
Zamfirescu, who was also vocal about disarmament, and filed a complaint with the disarmament committee at London's Lancaster House with a focus on nuclear threat, had a street named in her honour in the Romanian capital in 1993.
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