"We have thought long and hard about this decision. We have worked hard to create the right environment around the England team and need to consider what is in the best interests of the team, to ensure they are free from any distractions and able to focus on being successful on the pitch," Ashley Giles, ECB Managing Director of England Men's Cricket, said in a statement.
"I want to make it clear this is not the end of Alex's career as an England player. The ECB and the PCA will continue to aid Alex and work alongside his county club Nottinghamshire to give him the support he needs, to help him fulfill his potential as a professional cricketer," he said.
England named the 30-year-old in their squad for competing with Pakistan in a one-off T20 match and five-match ODI series. However, they will now have to name a replacement.
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