"In total, there have been 502 deaths and 271 people cured," said a health ministry bulletin published late on Friday, reporting on the outbreak in the east of the country.
"I believe we have prevented the spread of the epidemic in the big cities" in the region, he said.
"The teams also managed to contain its the spread of the epidemic to neighbouring countries," he added.
"The biggest problem is the high mobility of the population," the minister added.
Rwanda, Uganda and South Sudan, further north, were all now on alert, it added.
The security situation in the east of the country, where armed rebels have terrorised the population for years, has made treating the disease difficult.
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