Forwards Eder and Nani were surprise absentees from Portugal's World Cup squad with national team coach Fernando Santos opting instead for the youth of Andre Silva and Goncalo Guedes to play alongside superstar Cristiano Ronaldo.
Eder scored the extra-time winning goal in the Euro 2016 final against France but he was desperately out of form for Lokomotiv Moscow this season, scoring just four goals as his club side claimed the Russian Premier League title.
"From a human perspective, it's very hard to discard players who were with us at Euro 2016," admitted 63-year-old coach Santos.
"They have all contributed to writing a brilliant chapter in the history of Portuguese football. But I had to make choices that for me make a better puzzle."
Winger Guedes, 21, has impressed on loan at Valencia from Paris Saint-Germain this season, having struggled in France last term.
Portugal squad: Goalkeepers: Anthony Lopes (Lyon/FRA), Beto (Goztepe/TUR), Rui Patricio (Sporting Lisbon) Defenders: Bruno Alves (Glasgow Rangers/SCO), Cedric Soares (Southampton/ENG), Jos? Fonte (Dalian Yifang/CHN), Mario Rui (Napoli/ITA), Pepe (Besiktas/TUR), Raphael Guerreiro (Borussia Dortmund/GER), Ricardo Pereira (FC Porto), Ruben Dias (Benfica) Midfielders: Adrien Silva (Leicester City/ENG), Bruno Fernandes (Sporting Lisbon), Joao Mario (West Ham/ENG), Joao Moutinho (Monaco/FRA), Manuel Fernandes (Lokomotiv Moscow/RUS), William Carvalho (Sporting Lisbon), Bernardo Silva (Manchester City/ENG) Attackers: Andre Silva (AC Milan/ITA), Cristiano Ronaldo (Real Madrid/ESP), Gelson Martins (Sporting Lisbon), Goncalo Guedes (Valencia/ESP - on loan from Paris Saint-Germain/FRA), Ricardo Quaresma (Besiktas/TUR).
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)