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Study finds nanowire device to detect cancer with a urine test

ANI  |  Washington D.C. [U.S.A] 

In a new research, a group of researchers have developed a device that can detect microscopic levels of markers in the urine, an advance that could help non-invasively diagnose the deadly

Cells communicate with each other through a number of different mechanisms.

A less familiar mode of cellular transport is the extracellular vesicle (EV), which can be thought of as small "chunks" of a cell that are able to pinch off and circulate throughout the body to deliver cargo to other cells.

These messengers have become increasingly recognised as crucial mediators of cell-to-cell communication.

The scientists have developed a novel that can efficiently capture these EVs, and potentially use them to screen for

Talking about the research, study's explained, "EVs are potentially useful as clinical markers. The composition of the molecules contained in an EV may provide a diagnostic signature for The ongoing challenge for physicians in any field is to find a that allows them to monitor their patients on a regular basis -- for example, a simple test."

Yasui further added, "The content of EVs in is extremely low, at less than 0.01 percent of the total fluid volume. This is a major barrier to their diagnostic utility.

Our solution was to embed zinc oxide nanowires into a specialized polymer to create a material that we believed would be highly efficient at capturing these vesicles. Our findings suggest that the device is indeed quite efficient. We obtained a collection rate of over 99 percent, surpassing ultracentrifugation as well as other methods that are currently being used in the field."

To test the practicality of their device, researchers compared the microRNAs of EVs isolated from healthy patients with those isolated from patients who were already diagnosed with bladder, prostate, and other forms of

The technique required only one millilitre of and found a substantially greater number and different types of microRNAs compared with the standard ultracentrifugation approach.

The study was published in journal Science Advances.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Thu, December 28 2017. 05:27 IST
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