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Consuming fewer calories can improve cell performance: Study

ANI 

Diet consisting of fewer calories can improve cell performance, a recent study suggests.

The result of the study suggests that the number of calories a person eats directly influences the performance of different cells.

"We are looking at how changes to the diet affect metabolism and how that ends up changing the odds of having associated with aging," said Alicia Kowaltowski, of the study.

One of the group's experiments on mice shows how a can protect the brain from neuronal cell death associated with such as Alzheimer's, Parkinson's, and cerebral vascular accident (CVA).'

The mice were divided into two groups. The researchers calculated the average number of calories the group with no caloric restrictions would eat and then fed the other group 40% fewer calories. After 14 weeks, mice belonging to the two groups were given an injection containing a substance known to cause seizures, damage and neuronal cell death.

While the animals in the group that had no dietary restrictions had seizures, the animals whose calories had been restricted did not. The researchers then studied what occurred in vitro. To do that, they isolated the organelles of the brains of the mice, which were also divided into two groups: those that had unrestricted and those that had restricted When calcium was introduced to the medium, they noted that uptake was greater in the mitochondria belonging to the group that had ingested fewer calories.

Mitochondria are the organelles responsible for in cells. In the case of the mice subjected to a calorie restricted diet, mitochondria increased the calcium uptake capacity in situations where the level of that mineral was pathologically high.

In the pancreas, has shown to be capable of improving cell response to increased levels of blood glucose. The researchers reached this conclusion after conducting experiments using beta cell cultures that remain in the pancreatic islets and are responsible for producing insulin.

Blood serum from mice subjected to a variety of diets, similar to the study on the effects of on neurons, was used to nourish the cells cultivated in vitro.

Findings of the study were discussed in the meeting conducted by FAPESPWEEK

In the cells treated with the serum of animals that ate fewer calories, insulin secretion through the beta cells occurred normally: low when glucose was low and high when glucose was elevated. This did not occur in the animals that ate more calories (and became obese). The experiment showed that there may be a circulating blood factor that acutely modifies beta cell function.

When they measured oxygen consumption by the two groups of cells, they observed that it was higher in cells that received serum from animals subjected to Since respiration is responsible for the release of insulin during peak glucose, it was a sign that the cells generated more ATP under that condition.

Kowaltowski pointed out that understanding how metabolism works is essential for preventing and curing metabolic like It is well-known that being obese is one of the prognostic factors of unhealthy aging.

"Obese individuals are much more likely to have This includes like Alzheimer's, like cancer, and themselves, such as Type 2 diabetes, hyperlipidemia, and CVA. Obese people have a higher incidence of all of these," said the

By preventing obesity, we can prevent these diseases. However, the worldwide epidemic has not diminished even with constant warnings about the need for balanced and physical activity.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Tue, February 12 2019. 23:34 IST
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