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Hormone that protects women from liver cancer

IANS  |  London 

Researchers have discovered that a hormone -- present at higher levels in women -- can keep them away from cancer, suggesting the is more common in men.

The study showed that a potential contributor to this gender disparity is adiponectin, a hormone secreted by fat cells that helps control the body's metabolism.

The hormone activates two proteins inside cells, known as p38 and AMPK, that block cell proliferation and impair growth, said the study, published in the Journal of Experimental

"Circulating adiponectin levels have been reported to be higher in women than in men," said at the for Cardiovascular Research (CNIC) in

Similar to humans, male mice are more also prone to (HCC) -- the most common form of -- than females, as the increased levels of adiponectin in female mice protect them from HCC, the study said.

Inhibiting testosterone production in male rodents increased their adiponectin levels and reduced growth.

Importantly, the study suggested that adiponectin and metformin -- a common antidiabetic drug -- could be used as novel treatments for liver

Sabio said that adiponectin's role in HCC is controversial and needed further investigation.

Liver is the fourth leading cause of cancer-related deaths worldwide.



(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Fri, April 05 2019. 12:02 IST