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Punjab model to cure hepatitis C infection delivers results

IANS  |  Paris 

A decentralised system of care and the provision of free direct-acting antiviral agents (DAAs) can lead to high rates of cure among people with C (HCV) infection, shows a large-scale study in

The study presented at the International Liver 2018 in Paris, on Thursday validated the efficacy and safety of generic all-oral DAA regimens delivered using a decentralised algorithm-based public health model.

In the study, a population of almost 20,000 individuals completed treatment for C

"We have shown in our study that it is possible to cure more than 90 per cent of individuals with in a highly dispersed population using well-trained teams in government medical colleges and district hospitals, and widely available DAAs," said from the and Research, Chandigarh, and of the study.

"We believe the Model could be applied to many different populations with the aim of eliminating HCV," Dhiman said.

C (HCV) represents a major in India, with an estimated 12-18 million people infected.

The burden is particularly heavy in Punjab, owing to the high prevalence of risk factors such as unsafe medical practices -- including unsafe medical injections, and dental procedures -- and intravenous drug use.

The study assessed the feasibility of delivering decentralised care via three government medical colleges and 22 district hospitals, and required the training of approximately 90 medical specialists, pharmacists and data managers.

A cost-effective was developed using sofosbuvir-based regimens to treat all patients with infection, with regimens selected based on the presence/absence of and HCV

A total of 29,371 patients were enrolled in one year, of which 19,646 patients completed treatment.

Cure rates among individuals with (93.1 per cent) and without (92.4 per cent), and those with 3 (92.6 per cent) and other genotypes (93.1 per cent), were similar.

No major adverse events were reported, the researchers said.



(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Fri, April 13 2018. 14:08 IST