"Acting Secretary of Homeland Security Kevin K McAleenan determined that conditions in Venezuela threaten the safety and security of passengers, aircraft, and crew," Efe news quoted the department as saying on Wednesday.
"This determination is based on the ongoing political instability and increased tensions in Venezuela and associated inadvertent risk to flight operations," according to the statement from Homeland Security.
The suspension will remain in effect until US officials deem that conditions in Venezuela have changed sufficiently to accommodate the resumption of flights, Homeland Security said.
American Airlines, the last major US carrier providing scheduled service to and from Venezuela, suspended flights indefinitely on March 28.
United and Delta halted service to Venezuela in 2017.
Venezuela broke diplomatic relations with the US in January, after Washington recognized Juan Guaido, speaker of the opposition-controlled National Assembly, as interim president of the oil-rich country.
More than 50 other countries have joined the US in recognizing Guaido, who was known to fewer than 20 percent of Venezuelans before he proclaimed himself acting head of state.
Guaido has repeatedly called on the Venezuelan armed forces to rise up against Maduro, most recently on April 30, when the opposition leader went to a Caracas airbase with several dozen military defectors.
The uprising fizzled within hours.
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)