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Brain region that generates negative moods identified

Press Trust of India  |  Boston 

Scientists have identified a region that can generate negative moods which lead to irrational decision-making, a study has found.

Stimulating the caudate nucleus region causes animals to give far more weight to the anticipated drawback of a situation than its potential benefit, according to the study published in the journal Neuron.

Many patients with such as anxiety or experience negative moods that lead them to focus on the possible downside of a given situation more than the potential benefit.

Now, neuroscientists at (MIT) in the US have pinpointed the region that can generate this type of pessimistic

In tests in animals, they showed that stimulating this region, known as the caudate nucleus, induced animals to make more negative decisions.

They gave far more weight to the anticipated drawback of a situation than its benefit, compared to when the region was not stimulated.

This pessimistic could continue through the day after the original stimulation, researchers said.

The findings could help scientists better understand how some of the crippling effects of and anxiety arise, and guide them in developing new treatments.

"We feel we were seeing a proxy for anxiety, or depression, or some mix of the two," said Ann Graybiel, a at MIT.

"These psychiatric problems are still so very difficult to treat for many individuals suffering from them," said Graybiel.

Researchers have previously identified a neural circuit that underlies a specific kind of known as approach-avoidance conflict.

These types of decisions, which require weighing options with both positive and negative elements, tend to provoke a great deal of anxiety.

Her lab has also shown that dramatically affects this kind of decision-making: More stress usually leads animals to choose high-risk, high-payoff options.

In the new study, the researchers wanted to see if they could reproduce an effect that is often seen in people with depression, anxiety, or

These patients tend to engage in ritualistic behaviours designed to combat negative thoughts, and to place more weight on the potential negative outcome of a given situation.

This kind of negative thinking, the researchers suspected, could influence approach-avoidance

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Fri, August 10 2018. 16:20 IST