Woods, whose pursuit of Jack Nicklaus's record of 18 major victories has remained stalled at 14 since his 2008 US Open triumph, will put his fused spine and gradually improving game to the test at Shinnecock Hills in the 10th official start of his comeback season.
Mickelson, who turns 48 on Saturday, would become the oldest US Open champion and the second-oldest major winner in history should he pull off the feat.
"We're certainly on the back end of our careers," 42-year-old Woods admitted.
"We've been going at it for 20-plus years. That's a long time." But Woods and Mickelson remain front and center in the consciousness of golf fans -- with Woods's return from the injury wilderness and Mickelson's return to form electrifying galleries and fueling television viewership this year.
Three-time major-winner Jordan Spieth believes a career Grand Slam for Mickelson would trump an end to Woods's major drought.
"I think it makes a bigger difference for Phil than Tiger. I think there's a different meaning to those two." But Australian Jason Day disagrees.
"I think the biggest story would probably be Tiger," Day said. "Not taking anything away from Phil because winning the career Grand Slam is absolutely huge. But for what happened to Tiger, it's been 10 years, what he did in that period of when he dominated, and I think a lot of people are kind of chomping at the bit for him to come back and do something special -- seeing if he can get back to winning and beating Jack's record." Either outcome, however, would be a massive upset.
He'll tee it up on Thursday and Friday alongside Woods and second-ranked Justin Thomas, whose five victories last season included a first major title at the PGA Championship.
Mickelson will play the first two rounds alongside Spieth and four-time major winner Rory McIlroy, a winner on the US PGA Tour this year who will only be spurred by final-round failures at the Masters and the European PGA Championship at Wentworth.
- Mistakes magnified -
Reed noted that Shinnecock will present a vastly different challenge than that of Augusta National, although the US Golf Association has vowed no repeat of 2004, when brutal conditions on the final day saw some holes virtually unplayable.
"Even though it's a long golf course, you have to be able to work the ball both ways," Reed said. "You have to be able to flight the ball depending on wind.
"So any little detail of your golf game that's not on is going to be exposed." Spieth spoke of the "artistic approach" required.
"You have three or four different blind tee shots where you've just got to step up and really trust what you're hitting at," he said. "It really makes you think a lot." And, Woods noted, any mistakes are magnified in a major championship.
"As they should be," Woods added. "This is our toughest test.
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