Page 81 - Health Medical Pharma

AI can diagnose PTSD by analysing voices: Study

Researchers have developed an Artificial Intelligence (AI)-based computer programme that can help diagnose post-traumatic stress disorder (PTSD) in veterans by analysing their voices.

Novel model to predict lung cancer survival developed

Researchers have developed a deep-learning model that may help predict lung cancer survival and outcomes.

Study provides insights on marijuana and opioid use in people with cancer

A new study has revealed that people suffering from cancer use Marijuana to get relief from the pain. And shockingly, it is been seen that people residing in the US, consume the maximum amount of the drug.The study was published in the journal 'Cancer'.It is been noted that pain is a common symptom of cancer, and many patients affected with the disease do not receive adequate pain relief. In light of rapidly evolving marijuana legislation and a growing opioid epidemic, a team of researchers examined various trends in the self-disclosed use of marijuana and opioids among patients with cancer.After analyzing data from the US National Health and Nutrition Examination Survey between 2005 and 2014, the investigators matched 826 people with cancer to 1,652 people without cancer.Among survey respondents who had cancer, 40.3 per cent used marijuana within the past year, compared with 38.0 per cent of respondents without cancer. Also, people with cancer were more likely to use prescription ...

Genetic variants that protect against obesity could aid new weight loss medicines

According to recent study researchers have found a gene in people from the UK that protect them from obesity, type 2 diabetes, and heart diseases. Researchers also claim that the latest discovery could lead to the development of new medicines that could help to achieve or maintain weight-loss.The details were published in the Journal of Cell.Scientists have known for several years that genes can influence a person's weight. One of the gene (MC4R) plays a key role in regulating weight."This study drives home the fact that genetics plays a major role in why some people are obese -- and that some people are fortunate enough to have genes that protect them from obesity," says Professor Farooqi, one of the researcher.The discovery adds to recent work by the team which showed that some slim people have a genetic advantage when it comes to maintaining their weight."It doesn't mean that we can't influence our weight by watching what we eat, but it does mean the odds are stacked against some ..

Evenings are more productive for working out: study

A recent study suggests that evening work out can be more productive.The details were published in the Journal of Cell Metabolism.Research teams looked at the association between time of day and exercise performance primarily in mice.Because mice are nocturnal, one thing they had to do was translate mouse timing to human timing, by distinguishing between the active phase and resting phase of the mice rather than using numbers on the clock.Asher's group started by putting mice in treadmills at different times of day within their active phase. They examined the exercise capacity of mice upon different exercise intensities and regimens and found that overall exercise performance is substantially better in the "mouse evening" compared to the morning hours.These daily differences were diminished in mice that had mutant clocks -- supporting a potential role of the clock in the observed variance in exercise performance.To identify a potential determinant of daily variance in exercise ...

Obesity can impair learning, memory: Study

Obesity can break down our protective blood brain barrier resulting in problems with learning and memory, a study has found. Chronic activation of the receptor Adora2a on the endothelial cells that line this important barrier in our brain can let factors from the blood enter the brain and affect the function of our neurons, scientists said. The team from Augusta University in the US have shown that when they block Adora2a in a model of diet-induced obesity, this important barrier function is maintained. "We know that obesity and insulin resistance break down the blood brain barrier in humans and animal models, but exactly how has remained a mystery," said Alexis M Stranahan, neuroscientist at Augusta University and corresponding author of the study published in The Journal of Neuroscience. In the brain, adenosine is a neurotransmitter that helps us sleep and helps regulate our blood pressure; in the body it's also a component of the cell fuel adenosine triphosphate, or ATP. Adenosine .

Alembic Pharma gets USFDA nod for 2 generic products

Drug firm Alembic Pharmaceuticals Monday said it has received approvals from the US health regulator for its Teriflunomide tablets and Tobramycin ophthalmic solution. The company has received approval from the United States Food and Drug Administration (USFDA) for its abbreviated new drug application (ANDA) for Teriflunomide tablets in the strengths of 7 mg and 14 mg, Alembic Pharmaceuticals said in a filing to BSE. The product is generic version of Sanofi-Aventis US LLC's Aubagio tablets in the same strengths, it added. According to IQVIA, teriflunomide tablets, 7 mg and 14 mg have an estimated market size of USD 1.6 billion for 12 months ending December 2018, Alembic Pharma said. Teriflunomide tablets are indicated for the treatment of patients with relapsing forms of multiple sclerosis, Alembic Pharma said. The company has also received approval from the USFDA for its ANDA for Tobramycin ophthalmic solution USP, 0.3 per cent, it added. The product is generic version of Novartis ...

Gene editing may treat lethal lung diseases before birth

Scientists have used a gene editing tool to thwart a lethal lung disease in animals in which a harmful mutation causes death within hours after birth. The proof-of-concept study, published in the journal Science Translational Medicine, showed that in utero editing could be a promising new approach for treating lung diseases before birth. "The developing foetus has many innate properties that make it an attractive recipient for therapeutic gene editing," said William H Peranteau, an investigator at Children's Hospital of Philadelphia (CHOP) in the US. "Furthermore, the ability to cure or mitigate a disease via gene editing in mid- to late gestation before birth and the onset of irreversible pathology is very exciting. This is particularly true for diseases that affect the lungs, whose function becomes dramatically more important at the time of birth," Peranteau said in a statement. The lung conditions the team is hoping to solve -- congenital diseases such as surfactant protein ...

Obesity can break down protective blood brain barrier, trigger memory loss, finds study

A recent study claims that obesity can break down the protective blood-brain barrier, which can result in memory loss and learning issues, claim researchers.The details were published in the Journal of Neuroscience.The blood-brain barrier is comprised of high-density cells which restrict the passage of substances in the body from the bloodstream.Chronic activation of brain receptor Adora2a that line this important barrier in our brain can let factors from the blood enter the brain and affect the function of our neurons. Researchers have found that when they block Adora2a in a model of diet-induced obesity, an important barrier function is maintained."We know that obesity and insulin resistance break down the blood brain barrier in humans and animal models, but exactly how has remained a mystery," says Dr. Alexis M. Stranahan, neuroscientist.In the brain, adenosine is a neurotransmitter that helps us sleep and helps regulate our blood pressure; in the body, it's also a component of the

Alembic Pharmaceuticals receives USFDA approval for Tobramycin Ophthalmic Solution USP

Tobramycin Ophthalmic Solution USP, 0.3% have an estimated market size of US$ 9.6 million for twelve months ending December 2018 according to IQVIA.

Alembic Pharmaceuticals receives USFDA approval for Teriflunomide Tablets

Teriflunomide Tablets, 7 mg and 14 mg have an estimated market size of US$ 1.6 billion for twelve months ending December 2018 according to IQVIA. Alembic has settled the litigation and will launch the product as per the terms of the settlement.

USFDA issues EIR for Shilpa Medicare's R&D unit in Andra Pradesh

This R&D site has undergone an inspection by the USFDA during 11 February 2019 to 13 February 2019, wherein the company was issued a Form 483 with 1 (one) observation. Based on its responses and follow up actions, the USFDA has determined the inspection classification of this facility as Voluntary Action Initiated (VAI).

Shilpa Medicare receives USFDA approval for Busulfan Injection

According to IQVIA MAT Q4 2018 data, the US market for Busulfan Injection,6O mg/1O mL is approximately US$ 32.8 Million.

Hyderabad: Mother gives birth to quadruplets

A 24-year-old woman who gave birth to quadruplets here, was handed over her babies after 19 days of treatment on Sunday.Dr Sreedhar, Pediatrician and Managing Director of Neo BBC Hospital, while speaking to ANI said: "Hemalatha on 2 April gave birth to four baby child, two males and two females."Dr Sreedhar further said: "We have provided treatment to the babies for 19 days in our hospital. We handed the babies over to their mother today after their condition was stable. The mother was really happy to see her four babies healthy."According to the doctor, the delivery was preterm, hence Caesarean section was previously performed to take out the babies in Geetha maternity hospital.After the delivery, the babies were on the same day referred to Neo BBC Hospital for better treatment.

Odisha EC officials seek countermanding of Patkura polls

The returning officer of Patkura assembly constituency in Odisha on Sunday sought the countermanding of polls in the seat in the wake of the death of the BJD candidate. Sitting Biju Janata Dal MLA and candidate in the Patkura Assembly seat Bed Prakash Agarwal died at a hospital in Bhubaneswar on Saturday. He had been undergoing medical treatment for the past few days. The returning officer-cum-sub collector has apprised the Odisha Chief Electoral Officer, Surendra Kumar, of the candidate's death and sought countermanding of polls under section-52 of Representation of People Act, 1951, Kendrapara Collector, Dasarathi Satapathy said. The CEO has apprised the EC of the matter. Patkura was scheduled to go to the polls along with six Lok Sabha and 42 Assembly seats on April 29.

Genetic isolation, endogamy cause of infertility in Indian

Genetic isolation and endogamy, which is widespread among the Indian population, could be a major cause of infertility in the country's men, a study by the city-based Centre for Cellular and Molecular Biology (CCMB) said. According to CCMB, approximately one out of every seven couples is infertile worldwide, of which the male factors account for about 50 per cent of the cases. Several factors are known to cause male infertility including complete absence of sperm, low sperm production and motility, blockages that prevent sperm delivery due to illnesses and injuries, chronic health problems, lifestyle choices while genetic factors play a major role in most of these cases. A team of scientists at CCMB led by Chief Scientist K Thangaraj has been studying the genetic causes of male infertility for the last two decades, a release from the Centre said. "Y chromosome consists of several genes that are responsible for production of sperms, i.e. spermatogenesis. Deletions of ..

Scientists develop synthetic peptide that could inhibit toxic aggregates in Alzheimer's disease

Researchers have developed synthetic peptides that could target and reduce toxic protein aggregates, which are supposed to cause Alzheimer's disease, a new study finds.The study was published in the Proceedings of the National Academy of Sciences.Alzheimer's is a disease caused by the aggregation of the toxic protein. Neurons in the human brain make a protein called amyloid beta. Such proteins on their own, called monomers of amyloid beta, perform important tasks for neurons.But in the brains of people with Alzheimer's disease, amyloid beta monomers abandoned their jobs and get joined together. First, they form oligomers- small clusters of up to a dozen proteins- then longer strands and finally large deposits called plaques.For years, scientists believed that plaques triggered the cognitive impairments characteristic of Alzheimer's disease. But newer research implicated the smaller aggregates of amyloid beta as the toxic elements of this disease.The research reported that the ...

TN Guv bats for synergy betweeen modern & ancient medicines

Tamil Nadu Governor Banwarilal Purohit Sunday advocated interaction between modern and ancient medical traditions so that patients could reap its benefits. Inaugurating the "9th Reticon-2019," a conference on research and advances about the retina, Purhoit said newer technology in surgical management of retinal diseases offered a significant improvement in the success rate of surgeries. "While the system of medicine in which you have been trained has its own benefits, it is important that there is a continuous interaction between different medical traditions, ...whether modern or ancient, whether of the west or east, so that they could blend harmoniously and rid each other of their defects," he said. Lauding Dr Agarwal Eye Hospital for holding the meet of eminent opthalmologists, he said, "it is necessary to create a new model for health and healing, keeping the patient at the core of the treatment, without being fixated on a single system of medicine." Citing the adage .

Brain implements imperfect equation to understand truths about surroundings

A recent study claims that the brain implements imperfect mathematics principles which are used to determine truths about the surrounding environment.The study was published in the Journal of PLOS Computational Biology.To prove it, researchers Van den Berg and Stengard conducted an experiment with 30 volunteers who gave perception tests.These tests involved identifying whether ellipse shapes appearing on a screen were tilted clockwise or counterclockwise from vertical.Different tests incorporated sensory uncertainty in different ways, such as varying degrees of elongation of the ellipse shape, distractions in the form of nearby ellipses, and short display time of the ellipse on the screen.The researchers then analyzed their results against a series of different mathematical models."Our results suggest that human perception is blueprinted on optimal strategies, even though the brain's execution of these strategies seems to be imperfect. This novel concept provides a theoretical middle .

Gender stereotypes leaves imprint on human brains: Study

Society's expectations about gender roles alter the human brain at the cellular level, scientists say. Though the terms 'sex' and 'gender' are often used interchangeably by the average person, for neuroscientists, they mean different things, according to Nancy Forger, a professor at Georgia State University in the US. "We are just starting to understand and study the ways in which gender identity, rather than sex, may cause the brain to differ in males and females," said Forger. Sex is based on biological factors such as sex chromosomes and reproductive organs," whereas gender has a social component and involves expectations and behaviours based on an individual's perceived sex, researchers said. These behaviours and expectations around gender identity can be seen in "epigenetic marks" in the brain, which drive biological functions and features as diverse as memory, development and disease susceptibility. Forger said that epigenetic marks help determine which genes are expressed and ..