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Cook's comments come amid rising tensions between the US and China, with protectionist rhetoric from U.S. President Donald Trump sparking concern of increased trade friction between the two countries.
"The reality is countries that are closed, that isolate themselves, it's not good for their people," said Cook, in a rare public speech.
Apple has been singled out in Chinese media as a potential target for retaliation in the event of a trade war.
The Global Times warned last November if Trump triggered a trade war with China, Beijing would then target firms from Boeing to Apple in a "tit-for-tat" approach.