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Anti-psychotic drug may combat deadly breast cancer

Press Trust of India  |  London 

A commonly-used anti-psychotic drug could also be effective against a form of breast cancer, that is most difficult to treat, a study has found.

Researchers from the in the UK also showed that the drug, Pimozide, has the potential to treat the most common type of lung

Anti-psychotic drugs are known to have anti-properties, with some, albeit inconclusive, studies showing a reduced incidence of amongst people with

The research, published in the journal Oncotarget, is the first to identify how one of these drugs acts against triple negative breast cancer, with the potential to be the first targeted

"Triple negative has lower survival rates and increased risk of recurrence. It is the only type of for which only limited targeted treatments are available," said from the

"Our research has shown that Pimozide could potentially fill this gap. And because this drug is already in clinical use, it could move quickly into clinical trials," said El-Tanani.

The researchers tested Pimozide in the laboratory on triple negative cells, non-small cell cells and normal breast cells.

They found that at the highest dosage used, up to 90 per cent of the cancer cells died following treatment with the drug, compared with only five per cent of the normal cells.

They then tested the drug on mice implanted with in mice treated with Pimozide were 65 per cent smaller than in untreated mice and the number of reduced by up to 61 per cent.

The drug also helped to prevent the cancer spreading: treated mice had up to 94 per in the lung than mice who didn't receive Pimozide.

The study found that, in addition to reducing proliferation of cells and increasing the percentage of cells that died, the drug was able to reduce migration and invasion of these cancer cells.

It suppressed production of a protein, called VEGFR2, that supports blood supply to tumours, prevented production of an enzyme that is linked to and prevented the production of cells called myofibroblasts that help promote growth.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Wed, October 10 2018. 18:06 IST
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