Two pilots, a special "wellness" menu and more than seven weeks' worth of film and television entertainment were expected to accompany travellers on the 16,700-kilometre (10,400-mile) journey to the Big Apple.
For the flight crew -- which also includes two first officers and a 13-strong cabin contingent -- the work load will be broken up, the airline said, with each pilot having a minimum eight hours' rest during the flight.
But for passengers, the challenge will be what to do with all that down time when they're up in the air.
For those not packing a weighty novel (or two), there will be 1,200 hours of audio-visual entertainment to choose from.
Dining options will include dishes the airline says have been selected to promote well-being in the skies, with organic dishes on the menu.
The cabin has higher-than-normal ceilings, larger windows and lighting designed to reduce jet lag -- all part of an effort to lessen the stresses that can accompany almost a day on a plane.
"Research has shown that hydration and food intake are important factors (to consider), such as avoiding foods that cause gas or bloating as well as excessive alcohol," Rhenu Bhuller, a healthcare expert at consultancy Frost & Sullivan, told AFP.
"The biggest concern is Deep Vein Thrombosis from a combination of sitting for too long and also from dehydration," said Gail Cross, an associate consultant at the National University Hospital in Singapore.
The twin-engine plane that will make the journey uses a modified system that burns 25 percent less fuel than other aircraft of a similar size, Airbus said.
The flight from the city-state to Newark Airport can take up to 18 hours and 45 minutes under normal weather conditions, but the pilots will have something in reserve in an aircraft capable of flying more than 20 hours non-stop.
But the carrier is hoping that the introduction of more fuel-efficient planes will set cash registers ringing even as crude prices soar above USD 80.
"They are hoping to capitalise and exploit a very niche market," he told AFP.
Facing increasingly strong competition in recent years, Singapore Airlines has consolidated its low-fare subsidiaries and is strengthening its premium segment.
The company is the first airline in the world to operate the A350-900ULR plane. It received the first aircraft in September. Six more are due for delivery by the end of the year.
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)