Delegations from the Syrian regime and armed opposition groups are expected to participate along with representatives of the three guarantor states, Kazakhstan's foreign ministry said in a statement.
The situation on the ground in Idlib will be on the agenda of the talks, as well as "confidence-building measures" and the distribution of humanitarian aid.
De Mistura seemed frustrated at the most recent Astana talks in November, ruing a "missed opportunity" to move closer towards a political settlement.
Pedersen said that talks in Damascus Sunday with Syrian Foreign Minister Walid Muallem focused on a political settlement had been "substantial."
Russia, a key backer of Syrian President Bashar al-Assad, has taken a lead role in diplomatic efforts through the so-called "Astana process" with Iran and Turkey that has largely sidelined UN diplomacy.
The talks there began in January 2017.
Last month the Kazakh capital changed its name from Astana to Nur-Sultan, although the former name is still being used for the talks.
Syria's war has killed more than 370,000 people and displaced millions since the conflict began with the repression of anti-government protests in 2011.
The Syrian regime has made a military comeback with Russian military support since 2015, and now holds almost two-thirds of the country.
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